The Association for Information Science and Technology (ASIS&T) will host its 88th Annual Meeting November 14–18, 2025, at the Hyatt Regency Crystal City near Washington, D.C., with a virtual satellite meeting December 11–12. This year’s theme, “Difficult Conversations: The Role of Information Science in the Age of Human-Centered Artificial Intelligence,” invites the field to grapple with the social, ethical, and human implications of AI.